Nucleic Acid Synthesis
Medchemexpress LLC Pseudouridine | 1445-07-4 | 99.92% | 244.20 | 25 MG
Pseudouridine is an isomer of uridine and the most abundant modified nucleoside in non-coding RNA. It fine-tunes and stabilizes regional structures in rRNA and tRNA, maintaining their functions in mRNA decoding, ribosome assembly, processing, and translation. Pseudouridine-modified tRNA fragments can inhibit aberrant protein synthesis and hold promise for research on myelodysplastic syndrome (MDS)-related leukemia.
- Isomer of uridine
- Most abundant modified nucleoside in non-coding RNA
- Fine-tune and stabilize regional structures in rRNA and tRNA
- Maintain functions in mRNA decoding, ribosome assembly, processing, and translation
- Modified tRNA fragments can inhibit aberrant protein synthesis
- Hold promise for research on myelodysplastic syndrome (MDS)-related leukemia
- For research use only
Sigma Aldrich Fine Chemicals Biosciences Pseudouridine 9825MG
Pseudouridine is a C-glycosyl pyrimidine that consists of uracil having a beta-D-ribofuranosyl residue attached at position 5. The C-glycosyl isomer of the nucleoside uridine. It has a role as a fundamental metabolite. Pseudouridine is found in all species and in all classes of RNA except mRNA. It is formed by enzymes called pseudouridine synthases which post-transcriptionally isomerize specific uridine residues in RNA.
Medchemexpress LLC 4'-azidocytidine analogue | 876708-01-9 | ≥95.0% | 285.21 | C9H11N5O6 | 10 MG
Nucleoside-Analog-2 is a 4'-azidocytidine analogue that inhibits Hepatitis C virus replication and is supplied as a click-chemistry reagent. It contains an azide functional group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAC) and strain-promoted azide-alkyne cycloaddition (SPAAC) with suitable partners.
- 4'-azidocytidine analogue active against HCV replication.
- Contains an azide group for CuAAC and SPAAC click chemistry.
- Purity ≥95.0% and molecular weight 285.21 g/mol.
- Available as solid in multiple mg sizes and as 10 mM solution in DMSO.
- Powder storage: -20°C for 3 years or 4°C for 2 years; solution storage: -80°C for 2 years.
Cayman Chemical 6-thIo-2-DeoxygunosIn 25mg
A purine nucleoside analog; reduces infection of Calu-3 cells by SARS-CoV-2 (EC50 = 0.04 µM) but is also toxic to Calu-3 cells (CC50 = 1.14 µM); decreases tumor volume and increases the number of tumor cells with telomere dysfunction-induced foci in an A549 NSCLC mouse xenograft model at 2 mg/kg; increases the number of PD-1+ CD8+ T cells, as well as induces tumor regression when administered in combination with anti-PD-L1 in MC-38 murine colon carcinoma models
Cambridge Isotope Laboratories 2'-DEOXYCYTIDINE 5'-MONOPHOSPHATE (15N3, 96%), 10 MG
2'-DEOXYCYTIDINE 5'-MONOPHOSPHATE (15N3, 96%), 10 MG
Medchemexpress LLC Pseudouridine (standard) | 1445-07-4 | 100.0% | 244.20 | 10 MG
Pseudouridine (Standard) is the analytical standard of Pseudouridine, intended for research and analytical applications. It is the most abundant modified nucleoside in non-coding RNAs, and in rRNA and tRNA, it helps fine-tune and stabilize regional structure, maintaining their functions in mRNA decoding, ribosome assembly, processing and translation.
- Used as an analytical standard and reference standard.
- Commonly used in qualitative, quantitative, and methodological research experiments.
- Applicable in HPLC, GC, and MS.
Medchemexpress LLC 5-fluorocytidine | 2341-22-2 | MFCD00210953 | 97.0% | 261.21 g/mol | C9H12FN3O5 | 1 G
5-fluorocytidine is a fluorinated cytidine nucleoside that inhibits maturation of the 45S ribosomal RNA precursor and is provided as a characterized research reagent with storage and safety guidance from product datasheets and SDS.
- Fluorinated cytidine nucleoside.
- Inhibits maturation of the 45S ribosomal RNA precursor.
- Molecular formula C9H12FN3O5.
- Molecular weight 261.21 g/mol.
- Storage: 4°C under nitrogen; in solvent: -80°C for 6 months, -20°C for 1 month.
eMolecules 666847-77-4 | Medchem Express | 7-TFA-ap-7-Deaza-dG | 5mg | 719835964 | HY-138589 | 415.329 | C16H16F3N5O5
Medchem Express | 7-TFA-ap-7-Deaza-dG | 5mg | 719835964 | HY-138589 | 666847-77-4 | 415.329 | C16H16F3N5O5
Medchemexpress LLC 2'-O-Methyluridine | 2140-76-3 | 99.8% | 258.23 | 5 G
2'-O-Methyluridine is a modified nucleoside that can be found in *T. thermophile* tRNA. Its level in serum is decreased in patients with breast cancer. It can be incorporated into siRNA targeting the gene encoding apolipoprotein B, which decreases ApoB protein levels in HepG2 and prevents IFN-α production in isolated human PBMCs.
- Found in *T. thermophile* tRNA
- Decreased serum levels in breast cancer patients
- Can be incorporated into siRNA
- Decreases ApoB protein levels in HepG2
- Prevents IFN-α production in isolated human PBMCs
Medchemexpress LLC Nucleoside-Analog-1 | 876707-99-2 | >95.0% | C9H9N5O5 | 50 MG
Nucleoside-Analog-1 is a click chemistry reagent containing an azide group. It can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with molecules containing alkyne groups, and in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- Click chemistry reagent containing an azide group.
- Participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with molecules containing alkyne groups.
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
Medchemexpress LLC Pseudouridine | 1445-07-4 | MFCD00038458 | 99.9% | 244.20 | 5 MG
Pseudouridine is an isomer of uridine and the most abundant modified nucleoside in non-coding RNA. It fine-tunes and stabilizes regional structures in rRNA and tRNA, maintaining their functions in mRNA decoding, ribosome assembly, processing, and translation. Pseudouridine-modified tRNA fragments can inhibit aberrant protein synthesis and hold promise for research on myelodysplastic syndrome (MDS)-related leukemia.
- Most abundant modified nucleoside in non-coding RNA
- Fine-tunes and stabilizes regional structures in rRNA and tRNA
- Maintains functions in mRNA decoding, ribosome assembly, processing, and translation
- Inhibits aberrant protein synthesis
- Forms additional hydrogen bonds, stabilizing RNA and improving base stacking
- Found in all three phylogenetic domains of life
Alkali Scientific Cytidine, 25 G
Cytidine is a naturally occurring nucleoside composed of the nucleobase cytosine attached to a ribose sugar. It is an essential component of RNA and plays a fundamental role in nucleic acid synthesis and cellular metabolism. In molecular biology laboratories, cytidine is commonly used in studies related to RNA structure, nucleotide metabolism, and nucleic acid biochemistry. Researchers employ cytidine and its derivatives in enzymatic reactions, nucleic acid labeling experiments, and metabolic pathway investigations. Its role in RNA biosynthesis makes it important for experiments involving transcription, gene expression, and cellular signaling. Cytidine is widely used in biochemical assays and molecular biology research requiring reliable nucleoside substrates.
Selleck Chemical LLC Cytidine 5-triphosphate
Cytidine 5 -triphosphate is a pyrimidine nucleoside triphosphate that is involved in a variety of biochemical reactions It is used in the synthesis of RNA by RNA polymerases